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Teratogens and Cardiac Abnormalities

 

Potential Teratogen

Freq./ Cardiac Defects (%)

Most Common Malformations

Drugs

Alcohol
30

VSD, PDA, ASD

Amphetamines
5

VSD, PDA, ASD, TGA

Hydantoin
3

PS, AS, CA, PDA

Trimethadione
30

TGA, TF, HLHS

Lithium
10

Ebstein, TA, ASD

Thalidomide
10

TF, VSD, ASD, Truncus Art.

Retinoic Acid
10

VSD

Infections

Rubella
35

PA Stenosis, PDA, VSD, ASD

Maternal Conditions

Diabetes Mellitus
5

TGA,VSD,CA

SLE
40

Heart Block

Phenylketonuria
10

TF, VSD, ASD

VSD=ventricular septal defect, PDA=patent ductus arteriosus, ASD=atrial septal defect, TGA=transposition of great arteries, PS=pulmonary valve stenosis, AS=aortic stenosis, CA=coarctation of the aorta, TF=tetralogy of Fallot, HLHS=hypoplastic left-heart syndrome, TA=tricuspid atresia


Adapted from Hess LW, Hess DB, McCaul JF, Perry KG. Fetal Echocardiography. Obstetrics and Gynecology Clinics of North America.; WB Saunders and Company 17:41-79, 1990

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Ultrasound Educational Press     Go Top
Peter W. Callen, M.D.
Professor of Radiology, Obstetrics, Gynecology and Reproductive Science
University of California Medical Center, San Francisco, California

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